Effects of surface coating on the controlled release of vitamin B, frommesoporous silica tablets

ISL OpenIR > 青海盐湖研究所知识仓储

	Effects of surface coating on the controlled release of vitamin B, frommesoporous silica tablets
	Wu, Zhijian; Jiang, Yan; Kim, Taehoon; Lee, Kangtaek
	2007
发表期刊	JOURNAL OF CONTROLLED RELEASE
ISSN	0168-3659
卷号	119 期号:2 页码:215-221
摘要	The controlled release of vitamin B-1 (VB1, thiamine hydrochloride) from mesoporous silica tablets coated with a series of sol-gel coatings was investigated. Tetraethoxysilane (TEOS), n-propyltrietboxysilane (PTES), n-octyltriethoxysilane (OTES), bis(trimethoxysilyl)hexane (TSH), his (triethoxysilyl)octane (TSO), bis (trimethoxysilylpropyl)amine (TSPA), and bis[(3-trimethoxysilyl)propyl]ethylenediamine (TSPED) were used as precursors for the coatings. The effects of organosilane type and concentration, the number of coatings, drying temperature, and release media on VB1 release from the coated mesoporous silica tablets were comprehensively examined. The TSH, TSO, TSPA, and TSPED coatings were found to be more effective in suppression of release than the other coatings. VB1 release decreases with the increase in the number of coatings and drying temperature. It was found that there is an optimal coating solution concentration for the controlled release. In general, more VB1 is released in 0.01 M HCl solution than in 0.05 M phosphate buffer solution at pH 7.4 because of the electrostatic repulsions between the protonated VB1 cations and the positively charged mesoporous silica carrier/coatings. The experimental results show that drug release can be easily controlled by changing the organosilane type and the number of coating. The method used in this study is an effective and flexible way for controlled release due to the high drug loading and the easy control of release rate. (C) 2007 Elsevier B.V. All rights reserved. The controlled release of vitamin B-1 (VB1, thiamine hydrochloride) from mesoporous silica tablets coated with a series of sol-gel coatings was investigated. Tetraethoxysilane (TEOS), n-propyltrietboxysilane (PTES), n-octyltriethoxysilane (OTES), bis(trimethoxysilyl)hexane (TSH), his (triethoxysilyl)octane (TSO), bis (trimethoxysilylpropyl)amine (TSPA), and bis[(3-trimethoxysilyl)propyl]ethylenediamine (TSPED) were used as precursors for the coatings. The effects of organosilane type and concentration, the number of coatings, drying temperature, and release media on VB1 release from the coated mesoporous silica tablets were comprehensively examined. The TSH, TSO, TSPA, and TSPED coatings were found to be more effective in suppression of release than the other coatings. VB1 release decreases with the increase in the number of coatings and drying temperature. It was found that there is an optimal coating solution concentration for the controlled release. In general, more VB1 is released in 0.01 M HCl solution than in 0.05 M phosphate buffer solution at pH 7.4 because of the electrostatic repulsions between the protonated VB1 cations and the positively charged mesoporous silica carrier/coatings. The experimental results show that drug release can be easily controlled by changing the organosilane type and the number of coating. The method used in this study is an effective and flexible way for controlled release due to the high drug loading and the easy control of release rate. (C) 2007 Elsevier B.V. All rights reserved.
文献类型	期刊论文
条目标识符	http://ir.isl.ac.cn/handle/363002/2286
专题	青海盐湖研究所知识仓储
推荐引用方式 GB/T 7714	Wu, Zhijian,Jiang, Yan,Kim, Taehoon,et al. Effects of surface coating on the controlled release of vitamin B, frommesoporous silica tablets[J]. JOURNAL OF CONTROLLED RELEASE,2007,119(2):215-221.
APA	Wu, Zhijian,Jiang, Yan,Kim, Taehoon,&Lee, Kangtaek.(2007).Effects of surface coating on the controlled release of vitamin B, frommesoporous silica tablets.JOURNAL OF CONTROLLED RELEASE,119(2),215-221.
MLA	Wu, Zhijian,et al."Effects of surface coating on the controlled release of vitamin B, frommesoporous silica tablets".JOURNAL OF CONTROLLED RELEASE 119.2(2007):215-221.