| Recent Advances in the Synthesis of CF3- or HCF2-Substituted Cyclopropanes | |
Wu, Wen-Feng; Lin, Jin-Hong; Xiao, Ji-Chang; Cao, Yu-Cai; Ma, Yanfang
| |
| 第一作者 | Wu, Wen-Feng |
| 2021-03 | |
| 发表期刊 | ASIAN JOURNAL OF ORGANIC CHEMISTRY
 |
| ISSN | 2193-5807 |
| 卷号 | 10期号:3页码:485-495 |
| 摘要 | CF3- or HCF2-substituted cyclopropanes are of great interest in pharmaceutical chemistry and agrochemistry, and thus significant efforts have been directed towards the development of efficient methods for the installation of these motifs. This Minireview summarizes recent efforts for the construction of CF3- or HCF2-substituted cyclopropanes. CF3-cyclopropanes are usually synthesized by a transition-metal-catalyzed cyclopropanation of alkenes with a trifluoromethylcarbene generated in situ from a diazocompound, CF3CHN2 or CF3C(Ar)N-2. The synthesis of HCF2-cyclopropanes remains largely unexplored. Some difluoromethylcarbene reagents have been developed, such as HCF2CHN2, Ph2S+CH2CF2H TfO-, and difluoroacetaldehyde N-triftosylhydrazone (DFHZ-Tfs), and cyclopropanation of alkenes with these reagents could also occur by transition metal catalysis. These protocols may find great utility in the synthesis of biologically active molecules. |
| DOI | 10.1002/ajoc.202000723 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.isl.ac.cn/handle/363002/34333 |
| 专题 | 盐湖资源与化学实验室 |
| 推荐引用方式 GB/T 7714 | Wu, Wen-Feng,Lin, Jin-Hong,Xiao, Ji-Chang,et al. Recent Advances in the Synthesis of CF3- or HCF2-Substituted Cyclopropanes[J]. ASIAN JOURNAL OF ORGANIC CHEMISTRY,2021,10(3):485-495. |
| APA | Wu, Wen-Feng,Lin, Jin-Hong,Xiao, Ji-Chang,Cao, Yu-Cai,&Ma, Yanfang.(2021).Recent Advances in the Synthesis of CF3- or HCF2-Substituted Cyclopropanes.ASIAN JOURNAL OF ORGANIC CHEMISTRY,10(3),485-495. |
| MLA | Wu, Wen-Feng,et al."Recent Advances in the Synthesis of CF3- or HCF2-Substituted Cyclopropanes".ASIAN JOURNAL OF ORGANIC CHEMISTRY 10.3(2021):485-495. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Recent Advances in t（6245KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论