| Highly selective fluorescence probe with peptide backbone for imaging mercury ions in living cells based on aggregation-induced emission effect | |
Li, Yongxin; Zhang, Yaoling; Wang, Min ; Wang, Daojiong; Chen, Kai; Lin, Pengcheng; Ge, Yushu; Liu, Weisheng; Wu, Jiang
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| 第一作者 | Li, Yongxin |
| 2021-08-05 | |
| 发表期刊 | JOURNAL OF HAZARDOUS MATERIALS
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| ISSN | 0304-3894 |
| 卷号 | 415 |
| 摘要 | Mercury is an anthropogenic toxic heavy metal found in the environment. It is highly desirable to develop a fluorescence probe that can selectively and sensitively detect mercury ions using a turn-on response. This paper reports the successful development of a peptide fluorescence probe, TP-2 (TPE-Trp-Pro-Gln-His-Glu-NH2), which uses aggregation-induced emission effects and high selectivity to detect Hg2+. After fluorescence was activated, Hg2+ was efficiently detected using the change in fluorescence intensity. The detection limit for Hg2+ in the buffer solution was 41 nM (R2 = 0.9952). Owing to its high sensitivity, high cell permeability, and low biotoxicity, the probe could perform live cell imaging under biological conditions. This study demonstrated that TP2 can detect Hg2+ in complex biological environments. |
| DOI | 10.1016/j.jhazmat.2021.125712 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.isl.ac.cn/handle/363002/34361 |
| 专题 | 盐湖资源与化学实验室 |
| 推荐引用方式 GB/T 7714 | Li, Yongxin,Zhang, Yaoling,Wang, Min,et al. Highly selective fluorescence probe with peptide backbone for imaging mercury ions in living cells based on aggregation-induced emission effect[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,415. |
| APA | Li, Yongxin.,Zhang, Yaoling.,Wang, Min.,Wang, Daojiong.,Chen, Kai.,...&Wu, Jiang.(2021).Highly selective fluorescence probe with peptide backbone for imaging mercury ions in living cells based on aggregation-induced emission effect.JOURNAL OF HAZARDOUS MATERIALS,415. |
| MLA | Li, Yongxin,et al."Highly selective fluorescence probe with peptide backbone for imaging mercury ions in living cells based on aggregation-induced emission effect".JOURNAL OF HAZARDOUS MATERIALS 415(2021). |
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| Highly selective flu（5317KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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