| A fluorescein- based chemosensor for relay fluorescence recognition of Cu(II) ions and biothiols in water and its applications to a molecular logic gate and living cell imaging | |
Fu, Zhen-Hai ; Yan, Lu-Bin; Zhang, Xiaolong; Zhu, Fan-Fan; Han, Xin-Long; Fang, Jianguo; Wang, Ya-Wen; Peng, Yu
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| 第一作者 | Fu, Zhen-Hai |
| 2017-05-21 | |
| 发表期刊 | ORGANIC & BIOMOLECULAR CHEMISTRY
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| ISSN | 1477-0520 |
| 卷号 | 15期号:19页码:4115-4121 |
| 摘要 | Relay recognition of copper(II) ions and biothiols via a fluorescence on off on cascade was designed and realized as a new sequential combination of cations and small molecules. Probe 1 bearing a fluorescein skeleton was thus synthesized, which performed well in 100% HEPES buffer (pH = 7.0) solution, as a highly sensitive, selective fluorescence sensor for Cu2+. The limit of detection (LOD, 0.017 ppm) was obtained, and this value is much lower than 1.3 ppm, allowed by US EPA. The 1 : 1 complex generated from fast sensing of Cu2+ when excited at 491 nm, showed good relay recognition for biothiols (i.e., Cys, Hcy and GSH with low detection limits of 0.12 mu M, 0.036 mu M and 0.024 mu M, respectively) via remarkable fluorescence enhancement. The origin of this relay process was disclosed through ESI-MS and corresponding density functional theory (DFT) computations. Notably, probe 1 can be utilized for the construction of a molecular logic gate with the IMPLICATION function by using the above fluorescence changes. Moreover, this relay recognition was also applied to HepG2 cell imaging successfully. |
| DOI | 10.1039/c7ob00525c |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.isl.ac.cn/handle/363002/34529 |
| 专题 | 盐湖资源与化学实验室 |
| 推荐引用方式 GB/T 7714 | Fu, Zhen-Hai,Yan, Lu-Bin,Zhang, Xiaolong,et al. A fluorescein- based chemosensor for relay fluorescence recognition of Cu(II) ions and biothiols in water and its applications to a molecular logic gate and living cell imaging[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2017,15(19):4115-4121. |
| APA | Fu, Zhen-Hai.,Yan, Lu-Bin.,Zhang, Xiaolong.,Zhu, Fan-Fan.,Han, Xin-Long.,...&Peng, Yu.(2017).A fluorescein- based chemosensor for relay fluorescence recognition of Cu(II) ions and biothiols in water and its applications to a molecular logic gate and living cell imaging.ORGANIC & BIOMOLECULAR CHEMISTRY,15(19),4115-4121. |
| MLA | Fu, Zhen-Hai,et al."A fluorescein- based chemosensor for relay fluorescence recognition of Cu(II) ions and biothiols in water and its applications to a molecular logic gate and living cell imaging".ORGANIC & BIOMOLECULAR CHEMISTRY 15.19(2017):4115-4121. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| A fluorescein- based（7286KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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