中国科学院青海盐湖研究所机构知识库
Advanced  
ISL OpenIR  > 青海盐湖研究所知识仓储  > 期刊论文
题名: Comparison of amine-functionalized mesoporous silica particles foribuprofen delivery
作者: Lee, Kitae ;  Lee, Deokkyu ;  Lee, Hosub ;  Kim, Chang-Koo ;  吴志坚 ;  Lee, Kangtaek
刊名: KOREAN JOURNAL OF CHEMICAL ENGINEERING
出版日期: 2010
卷号: 27, 期号:4, 页码:1333-1337
英文摘要: We have prepared three different types of amine-functionalized silica particles: i) mesoporous silica (MESO1); ii) nonporous core-mesoporous shell silica (MESO2); iii) SBA-15 particles. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and nitrogen sorption experiment were used to study the morphology of the synthesized particles. To investigate the drug loading and subsequent release of the particles, ibuprofen was used as a model drug for oral delivery. Loading capacity of the particles in this work was found to be higher than that in the previous studies, and followed the order of MESO1>MESO2>SBA-15 particles. Release experiments showed the similar release rate for MESO1 and MESO2 particles from which only <40% of ibuprofen was released after 5 h. From SBA-15 particles, however, more than 80% of ibuprofen was released in 5 h at pH 4 and 7.4. Ibuprofen release from SBA-15 was slowest at pH 2 (similar to pH of stomach body) and fastest at pH 7.4 (similar to pH of proximal intestine). Difference in release rates was ascribed to the different morphology and pore structure of the carrier particles. We have prepared three different types of amine-functionalized silica particles: i) mesoporous silica (MESO1); ii) nonporous core-mesoporous shell silica (MESO2); iii) SBA-15 particles. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and nitrogen sorption experiment were used to study the morphology of the synthesized particles. To investigate the drug loading and subsequent release of the particles, ibuprofen was used as a model drug for oral delivery. Loading capacity of the particles in this work was found to be higher than that in the previous studies, and followed the order of MESO1>MESO2>SBA-15 particles. Release experiments showed the similar release rate for MESO1 and MESO2 particles from which only <40% of ibuprofen was released after 5 h. From SBA-15 particles, however, more than 80% of ibuprofen was released in 5 h at pH 4 and 7.4. Ibuprofen release from SBA-15 was slowest at pH 2 (similar to pH of stomach body) and fastest at pH 7.4 (similar to pH of proximal intestine). Difference in release rates was ascribed to the different morphology and pore structure of the carrier particles.
收录类别: SCI
语种: 英语
Citation statistics: 
内容类型: 期刊论文
URI标识: http://ir.isl.ac.cn/handle/363002/1911
Appears in Collections:青海盐湖研究所知识仓储(2014年之前)_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
10.1007_s11814-010-0179-6[1].pdf(1056KB)----开放获取
by-nc-sa
View Download

Recommended Citation:
Lee, Kitae,Lee, Deokkyu,Lee, Hosub,et al. Comparison of amine-functionalized mesoporous silica particles foribuprofen delivery[J]. KOREAN JOURNAL OF CHEMICAL ENGINEERING,2010,27(4):1333-1337.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Lee, Kitae]'s Articles
 [Lee, Deokkyu]'s Articles
 [Lee, Hosub]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Lee, Kitae]‘s Articles
 [Lee, Deokkyu]‘s Articles
 [Lee, Hosub]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
文件名: 10.1007_s11814-010-0179-6[1].pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2016  中国科学院青海盐湖研究所 - Feedback
Powered by CSpace