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Comparison of amine-functionalized mesoporous silica particles foribuprofen delivery
Lee, Kitae; Lee, Deokkyu; Lee, Hosub; Kim, Chang-Koo; Wu, Zhijian; Lee, Kangtaek
2010
Source PublicationKOREAN JOURNAL OF CHEMICAL ENGINEERING
ISSN0256-1115
Volume27Issue:4Pages:1333-1337
AbstractWe have prepared three different types of amine-functionalized silica particles: i) mesoporous silica (MESO1); ii) nonporous core-mesoporous shell silica (MESO2); iii) SBA-15 particles. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and nitrogen sorption experiment were used to study the morphology of the synthesized particles. To investigate the drug loading and subsequent release of the particles, ibuprofen was used as a model drug for oral delivery. Loading capacity of the particles in this work was found to be higher than that in the previous studies, and followed the order of MESO1>MESO2>SBA-15 particles. Release experiments showed the similar release rate for MESO1 and MESO2 particles from which only <40% of ibuprofen was released after 5 h. From SBA-15 particles, however, more than 80% of ibuprofen was released in 5 h at pH 4 and 7.4. Ibuprofen release from SBA-15 was slowest at pH 2 (similar to pH of stomach body) and fastest at pH 7.4 (similar to pH of proximal intestine). Difference in release rates was ascribed to the different morphology and pore structure of the carrier particles. We have prepared three different types of amine-functionalized silica particles: i) mesoporous silica (MESO1); ii) nonporous core-mesoporous shell silica (MESO2); iii) SBA-15 particles. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and nitrogen sorption experiment were used to study the morphology of the synthesized particles. To investigate the drug loading and subsequent release of the particles, ibuprofen was used as a model drug for oral delivery. Loading capacity of the particles in this work was found to be higher than that in the previous studies, and followed the order of MESO1>MESO2>SBA-15 particles. Release experiments showed the similar release rate for MESO1 and MESO2 particles from which only <40% of ibuprofen was released after 5 h. From SBA-15 particles, however, more than 80% of ibuprofen was released in 5 h at pH 4 and 7.4. Ibuprofen release from SBA-15 was slowest at pH 2 (similar to pH of stomach body) and fastest at pH 7.4 (similar to pH of proximal intestine). Difference in release rates was ascribed to the different morphology and pore structure of the carrier particles.
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.isl.ac.cn/handle/363002/1911
Collection青海盐湖研究所知识仓储
Recommended Citation
GB/T 7714
Lee, Kitae,Lee, Deokkyu,Lee, Hosub,et al. Comparison of amine-functionalized mesoporous silica particles foribuprofen delivery[J]. KOREAN JOURNAL OF CHEMICAL ENGINEERING,2010,27(4):1333-1337.
APA Lee, Kitae,Lee, Deokkyu,Lee, Hosub,Kim, Chang-Koo,Wu, Zhijian,&Lee, Kangtaek.(2010).Comparison of amine-functionalized mesoporous silica particles foribuprofen delivery.KOREAN JOURNAL OF CHEMICAL ENGINEERING,27(4),1333-1337.
MLA Lee, Kitae,et al."Comparison of amine-functionalized mesoporous silica particles foribuprofen delivery".KOREAN JOURNAL OF CHEMICAL ENGINEERING 27.4(2010):1333-1337.
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