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A fluorescein- based chemosensor for relay fluorescence recognition of Cu(II) ions and biothiols in water and its applications to a molecular logic gate and living cell imaging
Fu, Zhen-Hai1,2; Yan, Lu-Bin3; Zhang, Xiaolong1; Zhu, Fan-Fan1; Han, Xin-Long1; Fang, Jianguo1; Wang, Ya-Wen1; Peng, Yu1
2017-05-21
Source PublicationORGANIC & BIOMOLECULAR CHEMISTRY
Volume15Issue:19Pages:4115-4121
SubtypeArticle
AbstractRelay recognition of copper(II) ions and biothiols via a fluorescence "on off on" cascade was designed and realized as a new sequential combination of cations and small molecules. Probe 1 bearing a fluorescein skeleton was thus synthesized, which performed well in 100% HEPES buffer (pH = 7.0) solution, as a highly sensitive, selective fluorescence sensor for Cu2+. The limit of detection (LOD, 0.017 ppm) was obtained, and this value is much lower than 1.3 ppm, allowed by US EPA. The 1 : 1 complex generated from fast sensing of Cu2+ when excited at 491 nm, showed good relay recognition for biothiols (i.e., Cys, Hcy and GSH with low detection limits of 0.12 mu M, 0.036 mu M and 0.024 mu M, respectively) via remarkable fluorescence enhancement. The origin of this relay process was disclosed through ESI-MS and corresponding density functional theory (DFT) computations. Notably, probe 1 can be utilized for the construction of a molecular logic gate with the IMPLICATION function by using the above fluorescence changes. Moreover, this relay recognition was also applied to HepG2 cell imaging successfully.
WOS HeadingsScience & Technology ; Physical Sciences
WOS Keyword1,1'-BINAPHTHYL SCAFFOLD ; COLORIMETRIC CHEMOSENSORS ; BIFUNCTIONAL FLUORESCENT ; SELECTIVE DETECTION ; HYDROGEN-SULFIDE ; RECENT PROGRESS ; AQUEOUS-MEDIA ; AMINO-ACIDS ; PROBE ; HOMOCYSTEINE
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000401552700011
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Document Type期刊论文
Identifierhttp://ir.isl.ac.cn/handle/363002/4242
Collection青海盐湖研究所知识仓储
Affiliation1.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
2.Chinese Acad Sci, Qinghai Inst Salt Lakes, Key Lab Salt Lakes Resources & Chem, Xining 810008, Peoples R China
3.Sun Yat Sen Univ, Affiliated Hosp 6, Dept Pediat Surg, Guangzhou 510655, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Fu, Zhen-Hai,Yan, Lu-Bin,Zhang, Xiaolong,et al. A fluorescein- based chemosensor for relay fluorescence recognition of Cu(II) ions and biothiols in water and its applications to a molecular logic gate and living cell imaging[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2017,15(19):4115-4121.
APA Fu, Zhen-Hai.,Yan, Lu-Bin.,Zhang, Xiaolong.,Zhu, Fan-Fan.,Han, Xin-Long.,...&Peng, Yu.(2017).A fluorescein- based chemosensor for relay fluorescence recognition of Cu(II) ions and biothiols in water and its applications to a molecular logic gate and living cell imaging.ORGANIC & BIOMOLECULAR CHEMISTRY,15(19),4115-4121.
MLA Fu, Zhen-Hai,et al."A fluorescein- based chemosensor for relay fluorescence recognition of Cu(II) ions and biothiols in water and its applications to a molecular logic gate and living cell imaging".ORGANIC & BIOMOLECULAR CHEMISTRY 15.19(2017):4115-4121.
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