Rapid Access to Substituted Piperazines via Ti(NMe2)(4)-Mediated C-C Bond-Making Reactions

ISL OpenIR > 青海盐湖研究所知识仓储

	Rapid Access to Substituted Piperazines via Ti(NMe2)(4)-Mediated C-C Bond-Making Reactions
	Chen, Zhou 2,3; Wu, Jian 2; Chen, Yanmei 2; Li, Lei 2; Xia, Yuanzhi 1; Li, Yahong 2; Liu, Wei 2; Lei, Tao 3; Yang, Lijuan 2; Gao, Dandan3 ; Li, Wu 3
	2012-09-10
发表期刊	ORGANOMETALLICS
卷号	31 期号:17 页码:6005-6013
摘要	An efficient Ti(NMe2)(4)-mediated C-C bond-forming methodology toward substituted piperazines, the basic skeleton of several biologically active natural products, has been developed. In reactions of tridentate monoanionic ligands bearing a [-HCNCH2-] linkage with Ti(NMe2)(4), unusual [3 + 3] dimerized complexes through C-C coupling of the putative titanium aza-allyl complex intermediate could be obtained. These complexes contain substituted piperazine backbones and could give rise efficiently to substituted piperazine derivatives via hydrolysis. Treatment of Ti(NMe2)(4) with a series of tridentate dianionic and bidentate monoanionic ligands bearing the [-HCNCH2-] moiety only generated chelated titanium complexes from ligand exchange reactions. Mechanistic studies using DFT/M06 calculations revealed that the methylene in the [-HCNCH2-] moiety of titanium complexes bearing tridentate monoanionic ligands could be deprotonated intramolecularly by dimethylamide anion with an activation energy of about 22 kcal/mol. The resulting titanium aza-allyl complexes from this beta-H abstraction step then undergo a consecutive stepwise [3 + 2] cycloaddition/ring expansion reaction facilely to form the dimerized complex. However, beta-H abstractions for Ti complexes bearing tridentate dianionic and bidentate monoanionic ligands were energetically demanding, as the negative charges could not be stabilized by the adjacent groups in the possible intermediates, explaining the experimental outcomes that no C-C coupled products were formed.
语种	英语
引用统计
文献类型	期刊论文
条目标识符	http://ir.isl.ac.cn/handle/363002/5639
专题	青海盐湖研究所知识仓储中国科学院青海盐湖研究所盐湖资源综合利用工程技术中心
作者单位	1.Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China 2.Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China 3.Chinese Acad Sci, Qinghai Inst Salt Lakes, Key Lab Salt Lake Resources & Chem, Xining 810008, Peoples R China
推荐引用方式 GB/T 7714	Chen, Zhou,Wu, Jian,Chen, Yanmei,et al. Rapid Access to Substituted Piperazines via Ti(NMe2)(4)-Mediated C-C Bond-Making Reactions[J]. ORGANOMETALLICS,2012,31(17):6005-6013.
APA	Chen, Zhou.,Wu, Jian.,Chen, Yanmei.,Li, Lei.,Xia, Yuanzhi.,...&Li, Wu.(2012).Rapid Access to Substituted Piperazines via Ti(NMe2)(4)-Mediated C-C Bond-Making Reactions.ORGANOMETALLICS,31(17),6005-6013.
MLA	Chen, Zhou,et al."Rapid Access to Substituted Piperazines via Ti(NMe2)(4)-Mediated C-C Bond-Making Reactions".ORGANOMETALLICS 31.17(2012):6005-6013.