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Effects of surface coating on the controlled release of vitamin B, from mesoporous silica tablets
Wu, Zhijian; Jiang, Yan; Kim, Taehoon; Lee, Kangtaek
2007-06-01
发表期刊JOURNAL OF CONTROLLED RELEASE
卷号119期号:2页码:215-221
文章类型Article
摘要The controlled release of vitamin B-1 (VB1, thiamine hydrochloride) from mesoporous silica tablets coated with a series of sol-gel coatings was investigated. Tetraethoxysilane (TEOS), n-propyltrietboxysilane (PTES), n-octyltriethoxysilane (OTES), bis(trimethoxysilyl)hexane (TSH), his (triethoxysilyl)octane (TSO), bis (trimethoxysilylpropyl)amine (TSPA), and bis[(3-trimethoxysilyl)propyl]ethylenediamine (TSPED) were used as precursors for the coatings. The effects of organosilane type and concentration, the number of coatings, drying temperature, and release media on VB1 release from the coated mesoporous silica tablets were comprehensively examined. The TSH, TSO, TSPA, and TSPED coatings were found to be more effective in suppression of release than the other coatings. VB1 release decreases with the increase in the number of coatings and drying temperature. It was found that there is an optimal coating solution concentration for the controlled release. In general, more VB1 is released in 0.01 M HCl solution than in 0.05 M phosphate buffer solution at pH 7.4 because of the electrostatic repulsions between the protonated VB1 cations and the positively charged mesoporous silica carrier/coatings. The experimental results show that drug release can be easily controlled by changing the organosilane type and the number of coating. The method used in this study is an effective and flexible way for controlled release due to the high drug loading and the easy control of release rate. (C) 2007 Elsevier B.V. All rights reserved.
关键词Mesoporous Silica Vitamin B-1 Organosilane Coating Controlled Release
WOS标题词Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
关键词[WOS]CONTROLLED DRUG-DELIVERY ; IN-VITRO RELEASE ; DOPED HYBRID XEROGELS ; SOL-GEL ; SYNTHESIS PARAMETERS ; DYE ADSORPTION ; PORE STRUCTURE ; CARRIER ; MCM-41 ; PROPERTY
收录类别SCI
语种英语
WOS研究方向Chemistry ; Pharmacology & Pharmacy
WOS类目Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS记录号WOS:000247192800009
引用统计
文献类型期刊论文
条目标识符http://ir.isl.ac.cn/handle/363002/5819
专题青海盐湖研究所知识仓储
作者单位1.Huaqiao Univ, Coll Mat Sci & Engn, Quanzhou 362021, Peoples R China
2.Chinese Acad Sci, Qinghai Inst Salt Lakes, Xining 810008, Peoples R China
3.Yonsei Univ, Dept Chem Engn, Seoul 120749, South Korea
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Wu, Zhijian,Jiang, Yan,Kim, Taehoon,et al. Effects of surface coating on the controlled release of vitamin B, from mesoporous silica tablets[J]. JOURNAL OF CONTROLLED RELEASE,2007,119(2):215-221.
APA Wu, Zhijian,Jiang, Yan,Kim, Taehoon,&Lee, Kangtaek.(2007).Effects of surface coating on the controlled release of vitamin B, from mesoporous silica tablets.JOURNAL OF CONTROLLED RELEASE,119(2),215-221.
MLA Wu, Zhijian,et al."Effects of surface coating on the controlled release of vitamin B, from mesoporous silica tablets".JOURNAL OF CONTROLLED RELEASE 119.2(2007):215-221.
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