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Comparison of amine-functionalized mesoporous silica particles for ibuprofen delivery
Lee, Kitae1; Lee, Deokkyu1; Lee, Hosub1; Kim, Chang-Koo2,3; Wu, Zhijian4,5; Lee, Kangtaek1
2010-07-01
Source PublicationKOREAN JOURNAL OF CHEMICAL ENGINEERING
Volume27Issue:4Pages:1333-1337
SubtypeArticle
AbstractWe have prepared three different types of amine-functionalized silica particles: i) mesoporous silica (MESO1); ii) nonporous core-mesoporous shell silica (MESO2); iii) SBA-15 particles. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and nitrogen sorption experiment were used to study the morphology of the synthesized particles. To investigate the drug loading and subsequent release of the particles, ibuprofen was used as a model drug for oral delivery. Loading capacity of the particles in this work was found to be higher than that in the previous studies, and followed the order of MESO1>MESO2>SBA-15 particles. Release experiments showed the similar release rate for MESO1 and MESO2 particles from which only <40% of ibuprofen was released after 5 h. From SBA-15 particles, however, more than 80% of ibuprofen was released in 5 h at pH 4 and 7.4. Ibuprofen release from SBA-15 was slowest at pH 2 (similar to pH of stomach body) and fastest at pH 7.4 (similar to pH of proximal intestine). Difference in release rates was ascribed to the different morphology and pore structure of the carrier particles.
KeywordMesoporous Silica Ibuprofen Loading Release
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
WOS KeywordDRUG-DELIVERY ; CONTROLLED-RELEASE ; MORPHOLOGY ; SURFACE ; SYSTEM ; MCM-41
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Engineering
WOS SubjectChemistry, Multidisciplinary ; Engineering, Chemical
WOS IDWOS:000279666900046
Citation statistics
Document Type期刊论文
Identifierhttp://ir.isl.ac.cn/handle/363002/5956
Collection青海盐湖研究所知识仓储
盐湖资源与化学实验室
Affiliation1.Yonsei Univ, Dept Chem & Biomol Engn, Seoul 120749, South Korea
2.Ajou Univ, Dept Chem Engn, Suwon 442749, South Korea
3.Ajou Univ, Div Energy Syst Res, Suwon 442749, South Korea
4.Chinese Acad Sci, Key Lab Salt Lake Resources & Chem, Qinghai Inst Salt Lakes, Xining 810008, Peoples R China
5.Huaqiao Univ, Key Lab Funct Mat Fujian Higher Educ, Coll Mat Sci & Engn, Quanzhou 362021, Peoples R China
Recommended Citation
GB/T 7714
Lee, Kitae,Lee, Deokkyu,Lee, Hosub,et al. Comparison of amine-functionalized mesoporous silica particles for ibuprofen delivery[J]. KOREAN JOURNAL OF CHEMICAL ENGINEERING,2010,27(4):1333-1337.
APA Lee, Kitae,Lee, Deokkyu,Lee, Hosub,Kim, Chang-Koo,Wu, Zhijian,&Lee, Kangtaek.(2010).Comparison of amine-functionalized mesoporous silica particles for ibuprofen delivery.KOREAN JOURNAL OF CHEMICAL ENGINEERING,27(4),1333-1337.
MLA Lee, Kitae,et al."Comparison of amine-functionalized mesoporous silica particles for ibuprofen delivery".KOREAN JOURNAL OF CHEMICAL ENGINEERING 27.4(2010):1333-1337.
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