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Rapid Simultaneous Screening and Detection of 12 Anticoagulant Rodenticides in Food by Ultra-performance Liquid Chromatography-Triple Quadrupole/Linear Ion Trap Tandem Mass Spectrometry
Cao, Xiaoli1; Yang, Xiaoqian1; Liu, Zhong1; Jiao, Haitao1; Liu, Suhua1; Liu, Lanzheng1; Meng, Qingfen2
2017-11-01
Source PublicationFOOD ANALYTICAL METHODS
Volume10Issue:11Pages:3538-3547
SubtypeArticle
AbstractA rapid analytical method for the simultaneous screening and detection of 12 anticoagulant rodenticides in food samples was established based on modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) sample preparation method using an ultra-performance liquid chromatography-triple quadrupole/linear ion trap tandem mass spectrometry (UPLC-QTrap-MS/MS). Food samples were extracted and purified with modified QuEChERS method. The 12 anticoagulant rodenticides (warfarin, brodifacoum, difethialone, coumachlor, coumatetralyl, bromadiolone, chlorophacinone, difenacoum, diphacinone, pindone, valone, and flocoumafen) and the internal standard (warfarin-D-5) were separated within 6 min using an ACQUITY UPLC BEH-C18 column (1.7 mu m, 2.1 mm x 50 mm) and gradient elution with the mobile phase consisting of 5 mM ammonium acetate formate buffer and acetonitrile. The multiple reaction monitoring-information dependent acquisition-enhanced product ion (MRM-IDA-EPI) scanning was employed for detection. The calibration curves were linear (R (2) > 0.99) for all the compounds. The mean recoveries for the 12 analytes at three spiked levels (1x LOQ, 5x LOQ, and 10x LOQ) were in the range of 79.5-113.2% with RSDs of 1.8-13.2%.The limits of detection (LOD) for the 12 rodenticides ranged from 0.01 (warfarin) to 0.05 mu g/kg (diphacinone). The limit of quantification (LOQ) for the 12 rodenticides was between 0.02 (warfarin) and 0.10 mu g/kg (diphacinone). The developed method was more straightforward, less time and labor intensive, and more sensitive, selective, and accurate for screening multiple anticoagulant rodenticides, and it was successfully used in several poisoning cases.
KeywordAnticoagulant Rodenticides Multi-residue Analysis Modified Quechers Food Uplc-qtrap-ms/ms
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordFLUORESCENCE DETECTION ; HUMAN SERUM ; WHOLE-BLOOD ; WASTE-WATER ; BRODIFACOUM ; LIVER ; BROMADIOLONE ; PLASMA ; HPLC ; INTOXICATION
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology
WOS SubjectFood Science & Technology
WOS IDWOS:000412116000006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.isl.ac.cn/handle/363002/6256
Collection青海盐湖研究所知识仓储
Affiliation1.Jinan Municipal Ctr Dis Control & Prevent, Jinan 250021, Shandong, Peoples R China
2.Chinese Acad Sci, Qinghai Inst Salt Lakes, Xining 810008, Qinghai, Peoples R China
Recommended Citation
GB/T 7714
Cao, Xiaoli,Yang, Xiaoqian,Liu, Zhong,et al. Rapid Simultaneous Screening and Detection of 12 Anticoagulant Rodenticides in Food by Ultra-performance Liquid Chromatography-Triple Quadrupole/Linear Ion Trap Tandem Mass Spectrometry[J]. FOOD ANALYTICAL METHODS,2017,10(11):3538-3547.
APA Cao, Xiaoli.,Yang, Xiaoqian.,Liu, Zhong.,Jiao, Haitao.,Liu, Suhua.,...&Meng, Qingfen.(2017).Rapid Simultaneous Screening and Detection of 12 Anticoagulant Rodenticides in Food by Ultra-performance Liquid Chromatography-Triple Quadrupole/Linear Ion Trap Tandem Mass Spectrometry.FOOD ANALYTICAL METHODS,10(11),3538-3547.
MLA Cao, Xiaoli,et al."Rapid Simultaneous Screening and Detection of 12 Anticoagulant Rodenticides in Food by Ultra-performance Liquid Chromatography-Triple Quadrupole/Linear Ion Trap Tandem Mass Spectrometry".FOOD ANALYTICAL METHODS 10.11(2017):3538-3547.
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