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Rapid Simultaneous Screening and Detection of 12 Anticoagulant Rodenticides in Food by Ultra-performance Liquid Chromatography-Triple Quadrupole/Linear Ion Trap Tandem Mass Spectrometry
Cao, Xiaoli1; Yang, Xiaoqian1; Liu, Zhong1; Jiao, Haitao1; Liu, Suhua1; Liu, Lanzheng1; Meng, Qingfen2
2017-11-01
发表期刊FOOD ANALYTICAL METHODS
卷号10期号:11页码:3538-3547
文章类型Article
摘要A rapid analytical method for the simultaneous screening and detection of 12 anticoagulant rodenticides in food samples was established based on modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) sample preparation method using an ultra-performance liquid chromatography-triple quadrupole/linear ion trap tandem mass spectrometry (UPLC-QTrap-MS/MS). Food samples were extracted and purified with modified QuEChERS method. The 12 anticoagulant rodenticides (warfarin, brodifacoum, difethialone, coumachlor, coumatetralyl, bromadiolone, chlorophacinone, difenacoum, diphacinone, pindone, valone, and flocoumafen) and the internal standard (warfarin-D-5) were separated within 6 min using an ACQUITY UPLC BEH-C18 column (1.7 mu m, 2.1 mm x 50 mm) and gradient elution with the mobile phase consisting of 5 mM ammonium acetate formate buffer and acetonitrile. The multiple reaction monitoring-information dependent acquisition-enhanced product ion (MRM-IDA-EPI) scanning was employed for detection. The calibration curves were linear (R (2) > 0.99) for all the compounds. The mean recoveries for the 12 analytes at three spiked levels (1x LOQ, 5x LOQ, and 10x LOQ) were in the range of 79.5-113.2% with RSDs of 1.8-13.2%.The limits of detection (LOD) for the 12 rodenticides ranged from 0.01 (warfarin) to 0.05 mu g/kg (diphacinone). The limit of quantification (LOQ) for the 12 rodenticides was between 0.02 (warfarin) and 0.10 mu g/kg (diphacinone). The developed method was more straightforward, less time and labor intensive, and more sensitive, selective, and accurate for screening multiple anticoagulant rodenticides, and it was successfully used in several poisoning cases.
关键词Anticoagulant Rodenticides Multi-residue Analysis Modified Quechers Food Uplc-qtrap-ms/ms
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]FLUORESCENCE DETECTION ; HUMAN SERUM ; WHOLE-BLOOD ; WASTE-WATER ; BRODIFACOUM ; LIVER ; BROMADIOLONE ; PLASMA ; HPLC ; INTOXICATION
收录类别SCI
语种英语
WOS研究方向Food Science & Technology
WOS类目Food Science & Technology
WOS记录号WOS:000412116000006
引用统计
文献类型期刊论文
条目标识符http://ir.isl.ac.cn/handle/363002/6256
专题青海盐湖研究所知识仓储
作者单位1.Jinan Municipal Ctr Dis Control & Prevent, Jinan 250021, Shandong, Peoples R China
2.Chinese Acad Sci, Qinghai Inst Salt Lakes, Xining 810008, Qinghai, Peoples R China
推荐引用方式
GB/T 7714
Cao, Xiaoli,Yang, Xiaoqian,Liu, Zhong,et al. Rapid Simultaneous Screening and Detection of 12 Anticoagulant Rodenticides in Food by Ultra-performance Liquid Chromatography-Triple Quadrupole/Linear Ion Trap Tandem Mass Spectrometry[J]. FOOD ANALYTICAL METHODS,2017,10(11):3538-3547.
APA Cao, Xiaoli.,Yang, Xiaoqian.,Liu, Zhong.,Jiao, Haitao.,Liu, Suhua.,...&Meng, Qingfen.(2017).Rapid Simultaneous Screening and Detection of 12 Anticoagulant Rodenticides in Food by Ultra-performance Liquid Chromatography-Triple Quadrupole/Linear Ion Trap Tandem Mass Spectrometry.FOOD ANALYTICAL METHODS,10(11),3538-3547.
MLA Cao, Xiaoli,et al."Rapid Simultaneous Screening and Detection of 12 Anticoagulant Rodenticides in Food by Ultra-performance Liquid Chromatography-Triple Quadrupole/Linear Ion Trap Tandem Mass Spectrometry".FOOD ANALYTICAL METHODS 10.11(2017):3538-3547.
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